News
News Home
Quick Bites
Exploradio
News Archive
News Channel
Special Features
NPR
nowplaying
On AirNewsClassical
Loading...
  
School Closings
WKSU Support
Funding for WKSU is made possible in part through support from the following businesses and organizations.

Greater Akron Chamber

The Holden Arboretum

Wayside Furniture


For more information on how your company or organization can support WKSU, download the WKSU Media Kit.

(WKSU Media Kit PDF icon )


Donate Your Vehicle to WKSU

Programs Schedule Make A Pledge Member BenefitsFAQ/HelpContact Us
Health and Medicine




Exploradio: Vaccines 2.0
A breakthrough in vaccine technology could provide protection against cancer, arthritis, and AIDS, but funding new vaccine testing is a major hurdle
by WKSU's JEFF ST. CLAIR
This story is part of a special series.


Reporter / Host
Jeff St. Clair
 
Dr. Kenneth Rosenthal is co-author of the Microbiology textbook used at NeoMed, and a professor of immunology. He co-discovered a novel mechanism for controlling the immune response and is testing new vaccines for breast cancer, Herpes Simplex virus, rheumatoid arthritis and HIV.
Courtesy of Jeff St.Clair
Download (WKSU Only)
In The Region:

The Centers for Disease Control expects 145 million flu shots will be given out this season.   Those vaccines -- for the flu and more than a dozen diseases  from polio to hepatitis -- are a big part of our strategy for disease prevention.

But developing vaccines for diseases like cancer, arthritis, or AIDS is proving more difficult.

In this week’s Exploradio, WKSU’s Jeff St.Clair finds that a new type of vaccine technology could change all that.

Exploradio: Vaccines 2.0

Other options:
Windows Media / MP3 Download (4:29)


(Click image for larger view.)

From smallpox to HPV
The idea of inoculation dates back to the 1500’s in China, where healthy people, given a dose of small pox, contracted a mild case of the disease and gained lifelong immunity.  In 18th century England, Edward Jenner’s experiments fighting small pox with inoculations of cow pox led to the science of immunology.  

The 20th century saw vaccines developed for diphtheria, pertussis, tetanus, polio, mumps, rubella, and hepatitis.  The human papillomavirus vaccine to fight cervical cancer came out three years ago.

But Ken Rosenthal, an immunology researcher at the Northeast Ohio Medical University, says producing new vaccines is an increasingly uphill battle.

“It takes a billion dollars to take a vaccine like that to market.”

A great LEAPS forward
Testing is expensive and time consuming.  A vaccine must be proven safe. It has to work on enough people to be effective.  And inoculations only protect against a few types of infections.

But Rosenthal says new discoveries in immunology are allowing his team at NEOMED to develop vaccines that someday could prevent a new range of diseases.

“This vaccine is for Herpes simplex virus,” Rosenthal says as he rummages around in a freezer in his lab. “And another one here is for the breast cancer vaccine; we also have one for HIV in this freezer, and we have the rheumatoid arthritis one in there as well.”  

Unlike traditional vaccines, these new vaccines trigger the immune response without introducing the disease.  They work through an alternative approach he calls LEAPS.

“Ligand Epitope Antigen Presentation System - when you’re from Akron you make acronyms.”

LEAPS, he says, fights infections by re-programming the cells that orchestrate the body’s immune response. 

“These vaccines will trigger the development of a very important white blood cell, so that it becomes the optimal white blood cell to initiate and direct the subsequent immune responses. It’s called the dendritic cell.”

Controlling the immune response
Dendritic cells hang out in parts of your body where infections can start, like blood vessels in your skin, lungs, or lymph glands.  When a virus or a foreign cell part floats by, the dendritic cells decide whether to initiate an attack, or let it pass.  Rosenthal say LEAPS allows him to control that process.

“So we create the dendritic cells that direct the immune response properly, and they do it.”

The dendritic cell’s weapon of choice is the immune system’s highly adaptable and effective T-cell.

“If you can get the dendritic cells in the right form, they will direct the T-cells of the person to do the job.”

The LEAPS vaccine creates immunity at the top of the immune cascade, without infecting the person, or causing inflammation.

Instead of creating antibodies for every possible mutation of a virus, the LEAPS vaccine teaches T-cells to recognize broad types of invaders.   

T-cells can also be programmed to destroy harmful tissue disguised as our own self, like tumor cells,

“and then not only attack from different sides of the tumor cell, but also work in different kinds of people who may recognize different parts of a protein because of their particular immune system.”

Keeping the balance in the body
Back in his lab, Rosenthal says the immune system is not just an army ready to attack; it’s a balance we maintain.  And every person is different.

“To be healthy we have to have a balance between the inflammatory and the repair mechanisms in the body.  In some people, the balance favors inflammation and for some people it favors repair.”

He says by helping the body achieve a healthy balance of immune responses, his new vaccines can not only prevent, but even treat ,auto-immune diseases like rheumatoid arthritis.

Still, only one LEAPS vaccine, for Herpes Simplex virus, is being commercially developed through a Virginia-based company called CEL –SCI, which has licensed the technology.

Rosenthal says his work represents what’s possible rather than what’s likely, at least for now.

“It’s still pie in the sky, something we’re looking for, aspiring toward but we’re not there yet.”

He won’t even hazard a guess on when the new vaccines could reach clinical trials, or where the billion dollars to complete the testing could come from.
Add Your Comment
Name:

Location:

E-mail: (not published, only used to contact you about your comment)


Comments:




 
Page Options

Print this page

E-Mail this page / Send mp3

Share on Facebook





Stories with Recent Comments

Farm-to-School: Cafeteria lunch is fresh and local at Tallmadge High School
Great job Tallmadge City Schools! So glad to have a progressive business manager and superintendant!

World premiere at Cleveland Institute of Music is fanfare for a new theme
J'ai une grande admiration pour Daniil Trifonov que j'ai vu en concert deux fois à Paris je ne lui trouve pas d'égal c'est un ange tombe du ciel

Kent's journalism school faculty protest presidential search secrecy
There really was too much secrecy behind the selection process. Hopefully the letter by the faculty members will convince the board to provide more information ...

Belgian cargo ship creates new export route between Antwerp and NEO
The vessel is registered in Amsterdam, The Netherlands. Not in Belgium ;)

Exploradio: Tracking Ohio's champion trees
Absolutely loved this story. We lost 3 of our larger ash trees last year due to EAB. Big, beautiful trees are something to be treasured, and many times they tru...

Ohio's rules on fracking and earthquakes are a first
I'm right in the middle of the issue. Like oil independence, but hope there is pre- and current-drilling assurance re dangers from pollution, earthquakes and th...

Bridgestone exec indictments are latest step in a billion-dollar price-fixing case
Why is O.P.E.C Not investigated and charges brought against it and it's member companies? It sounds exactly the same...

Ohio's new drilling rules rely on known earthquake faults
requiring drillers to place seismic monitors when they drill within 3 miles of known fault lines. This comment really upsets me!! What good does an instrument t...

Kasich's gubernatorial ad focuses on his blue-collar roots
John Kasich is the biggest con-man in America. He will say one thing and then do the opposite. He is terribly successful at fooling the public and he is worki...

Cab drivers who refuse to drive Gay Games taxis will be replaced
the irony is that most americans distrust or hate muslims much more than they hate gays!! silly ignorant bigots-GO HOME!!!

Copyright © 2014 WKSU Public Radio, All Rights Reserved.

 
In Partnership With:

NPR PRI Kent State University

listen in windows media format listen in realplayer format Car Talk Hosts: Tom & Ray Magliozzi Fresh Air Host: Terry Gross A Service of Kent State University 89.7 WKSU | NPR.Classical.Other smart stuff. NPR Senior Correspondent: Noah Adams Living on Earth Host: Steve Curwood 89.7 WKSU | NPR.Classical.Other smart stuff. A Service of Kent State University